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Obstacles facing therapeutic trials in systemic lupus erythematosus (SLE) include the low incidence, seriousness, complexity, and clinical polymorphism of the disease. A large-scale multicenter design has been required in most cases. Over the last few years, several biologics have been evaluated as treatments for lupus nephritis or for the skin and joint manifestations of SLE. The central role for...
Les études thérapeutiques sur le lupus érythémateux systémique doivent prendre en compte sa rareté, sa gravité, sa complexité et son polymorphisme clinique. Pour cette raison, elles sont difficiles à mener et presque toujours réalisées sur une grand échelle multicentrique. Plusieurs biothérapies sont proposées depuis quelques années dans les atteintes néphritiques ou cutanéoarticulaires. Le rôle central...
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