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Gene therapy using cells as vectors to achieve secretion of therapeutic proteins may hold promise in the treatment of chronic diseases. Cell-based gene therapy with xenogeneic cells secreting antiinflammatory cytokines (IL-4, IL-13, or IL-1 receptor type II) has been found effective in mice with collagen-induced arthritis (CIA), a model for human rheumatoid arthritis. Autologous cells engineered to...
La thérapie génique par vecteurs cellulaires autorisant la sécrétion de protéines thérapeutiques est prometteuse dans le traitement des maladies chroniques. Nous avons déjà montré, dans l'arthrite au collagène (AEC) chez la souris, modèle de polyarthrite rhumatoïde (PR), qu'il était possible de traiter la maladie par thérapie cellulaire avec des cellules xénogéniques secrétant des cytokines anti-inflammatoires...
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