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Long non‐coding RNAs (lncRNA) modulate gene expression at the epigenetic, transcriptional and post‐transcriptional levels and are involved in tumorigenesis. They can form complex secondary and tertiary structures and have been shown to act as precursors, enhancers, reservoirs and decoys in the complex endogenous RNA network. They were first reported in relation to oral squamous cell carcinoma (OSCC)...
Background
Long non‐coding RNAs (lncRNAs) have important roles in regulating gene expression pertaining to cell proliferation, survival, migration and genomic stability. Dysregulated expression of lncRNAs is implicated in cancer initiation, progression and metastasis.
Objectives
To explore, map and summarize the extent of evidence from clinical studies investigating the differential expression...
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