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TRAM-34 has been demonstrated to inhibit intermediate-conductance Ca2+-activated K+ channels in a wide variety of cell types, including immune cells. In the present study, we investigated effects of TRAM-34 on microglial cells stimulated with lysophosphatidylcholine (LPC). LPC-induced increases in the intracellular Ca2+ concentration of microglial cells were effectively reduced in the presence of...
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