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This paper reviews procedures for screening, identification and quantification of drugs, poisons and their metabolites in biosamples, and the corresponding work-up procedures. Gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry are mostly used today in analytical toxicology. Selection of the most appropriate biosample, e.g., ante/postmortem blood, urine, or tissues or...
Substances taken for nonmedical reasons, usually for their mind-altering effects, are called drugs of abuse. The use of psychoactive plants as drugs of abuse has had a long tradition. Most commonly abused drugs extracted from or based on natural products are illicit substances, such as cannabis products, morphine, or cocaine, but other herbal products used to produce a “high” are becoming increasingly...
The reliability of analytical data is very important to forensic and clinical toxicologists for the correct interpretation of toxicological findings. This makes (bio)analytical method validation an integral part of quality management and accreditation in analytical toxicology. Therefore, consensus should be reached in this field on the kind and extent of validation experiments as well as on acceptance...
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