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Decorin was reported to bind transforming growth factor-beta (TGF-β 1 ) and neutralise some of its activity as a key regulator of wound contraction and hypertrophic scar formation. In this study, we investigated whether recombinant human decorin affected TGF-β 1 -induced fibroblast contractile activity, by using fibroblast-populated collagen lattice with decorin added to the collagen...
Hypertrophic scarring remains a major problem for patients who have suffered deep burns. The pathophysiology underlying hypertrophic scar formation may be driven by the biological activity of transforming growth factor beta1 (TGF-β 1 ). Decorin is a human proteoglycan that inactivates the effect of TGF-β 1 and therefore displays a beneficial effect of antifibrosis in various tissues...
The purpose of this study was investigation of the potential to isolate mesenchymal stem cells (MSCs) from human umbilical cord blood (UCB) and differentiate them into epithelial cells in mouse skin tissues. Mononuclear cells (MNCs) from UCB (UCB–MNCs) were isolated and induced to MSCs in culture. UCB–MSCs were transfected with pEGFP and labeled with PKH26 dye. eGFP-transfected and PKH26-labeled UCB-derived...
The propose of the present study is to investigate the effects of lanthanum chloride (LaCl 3 ), a rare earth compound, on extracellular matrix molecules in rat wound tissues, hoping to provide a clue for further study in reducing excessive extracellular matrix formation in trauma and burn, as well as in fibrous disorders. In order to elucidate its action mechanism, we investigated its effects...
This study is to constitute a composite skin substitute with epidermal stem cells (ESCs) and fibroblasts on collagen sponge. ESCs were selected by rapid attachment to collagen IV for 10min. Collagen was extracted from rat's tail. The matrix lattice was fabricated by freeze-dryer and cross-linked with glutaraldehyde. Fibroblasts were inoculated on collagen sponge and cultured for 1 week prior to inoculation...
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