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BACKGROUNDRecurrence and toxicity occur commonly among patients with rectal cancer who are treated with 5‐fluorouracil (5‐FU). The authors hypothesized that genetic variation in folate‐metabolizing genes could play a role in interindividual variability. The objective of the current study was to evaluate the associations between genetic variants in folate‐metabolizing genes and clinical outcomes among...
Dietary polyunsaturated fatty acids (PUFAs) can be converted to prostaglandins and leukotrienes. Oxygenation of omega-6 PUFAs generally results in the production of pro-inflammatory mediators, whereas oxygenated products of omega-3 (n-3) PUFAs generally have lower inflammatory activity. We hypothesize that elevated n-3 PUFA intakes from fish are associated with lower risk of colorectal cancer among...
C‐reactive protein (CRP), a biomarker of inflammation, has been shown to be influenced by genetic variation in the CRP gene. In this study, we test the hypothesis that genetic variation in CRP influences both the risk of developing colon and rectal cancer and survival. Two population‐based studies of colon cancer (n = 1,574 cases, 1,970 controls) and rectal (n = 791 cases, 999 controls) were conducted...
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