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Acute kidney injury (AKI) is frequently triggered by abundant reactive oxygen/nitrogen species (RONS) and leads to high morbidity and mortality in clinic. Unfortunately, the current clinical treatment options are only limited to supportive care, and hence, the development of nano‐antioxidants with high kidney enrichment is an attractive novel strategy for AKI management. Herein, self‐assembled ultrasmall...
In article number 2005113, Peng Huang and co‐workers develop biodegradable self‐assembled ultrasmall nanodots, which are composed of iron ion, gallic acid, and polyvinylpyrrolidone, as broad‐spectrum reactive oxygen/nitrogen species scavengers (RONS) with preferential kidney accumulation and rapid excretion to alleviate both glycerinum‐ and cis‐platinum‐induced acute kidney injury in mice.
Acute kidney injury (AKI) is frequently associated with oxidative stress and causes high mortality annually in clinics. Nanotechnology‐mediated antioxidative therapy is emerging as a novel strategy for the treatment of AKI. Herein, a novel biomedical use of the endogenous biopolymer melanin as a theranostic natural antioxidant defense nanoplatform for AKI is reported. In this study, ultrasmall Mn2+...
Background Acute kidney injury (AKI) is one of the most common emergencies and severe diseases in the clinic. We sought to verify whether remote ischemic preconditioning (RIPC) has a protective effect on the kidney of child with congenital heart disease undergoing cardiopulmonary bypass (CPB) surgery. We hypothesized it may be related to the up-regulation of microRNA-21 (miR-21). Methods We performed...
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