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Pirarubicin (THP) is a widely used antitumor drug in clinical practice, but its cardiotoxicity limits its use. The aim of this study was to investigate the protective effect and mechanism of knockdown of lncRNA Miat in THP‐induced cardiotoxicity. The extent of damage to immortalized cardiomyocytes in mice was assessed by CCK8, TUNEL, ROS, Ca2+, RT‐qPCR, and Western blot. The relative levels of Miat...
Objective
Pirarubicin (THP) is a widely used antitumor drug in clinical practice, but its cardiotoxicity limits its use. There is an urgent need to find drugs to alleviate the cardiotoxicity of THP. This study aimed to investigate the effect and mechanism of miR‐494‐3p on THP‐induced cardiomyocytes.
Methods
THP induced immortalized mouse cardiomyocytes HL‐1, silenced or overexpressed miR‐494‐3p...
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