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In this research, a novel derivative of chitooligosaccharides (COS) was synthesized by covalently linking gallic acid and COS (gallate-COS) via carbodiimide to improve cellular antioxidant activity. The direct intracellular radical scavenging effect of gallate-COS by 2′,7′-dichlorofluorescin diacetate (DCFH-DA) method, and the inhibition of oxidation of cellular macromolecules, such as DNA, protein...
Porous, biodegradable and biocompatible chitosan, chitosan with natural hydroxyapatite derived from Thunnus Obesus bone (chitosan/HAp) and chitosan grafted with functionalized multiwalled carbon nanotube in addition to HAp (f-MWCNT-g-chitosan/HAp) scaffolds were prepared for the first time via freeze-drying method and physiochemically characterized as bone graft substitutes. The cross-linkages in...
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