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In double-blind trials in Bangladesh, 88 adults, and 79 children (8–10 years) were randomized to receive either a single oral dose of 1×10 4 , 1×10 5 or 1×10 6 CFU of SC602 (a live, attenuated Shigella flexneri 2a strain vaccine) or placebo. In the adult outpatient 1×10 6 CFU group, severe joint pain and body aches were reported by one and two vaccinees respectively...
Twenty-eight adults received between 10 2 and 10 8 colony forming units of live Shigella dysenteriae type-1 vaccine SC599, attenuated by deletion of invasion (icsA), iron chelation (ent, fep) and shiga toxin A-subunit (stxA) genes, followed by ciprofloxacin on day 4. Dose-independent diarrhea or change in bowel habit was seen in 3 subjects, without dysentery, vaccinaemia or serious...
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