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The chemokine CXCR4 receptor is over-expressed in a wide variety of tumors. In this study, AMD3100, which was a prototype non-peptide antagonist of CXCR4 receptor, was labeled with 99m Tc. 99m Tc–AMD3100 was verified by thin layer radio chromatography (TLRC). The tumor-localizing properties of 99m Tc–AMD3100 were evaluated and proved in mice bearing Hep-G2 tumor xenograft....
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