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In the osteoporotic microenvironment, the acidic microenvironment generated by excessive osteoclasts not only causes irreversible bone mineral dissolution, but also promotes reactive oxygen species (ROS) production to induce osteoblast senescence and excessive receptor activator of nuclear factor kappa‐B ligand (RANKL) production, which help to generate more osteoclasts. Hence, targeting the acidic...
Efficient electrocatalysts capable of operating continuously at industrial ampere‐level current densities are crucial for large‐scale applications of electrocatalytic water decomposition for hydrogen production. However, long‐term industrial overall water splitting using a single electrocatalyst remains a major challenge. Here, bimetallic polyphthalocyanine (FeCoPPc)‐anchored Ru nanoclusters, an innovative...
The contrast agents and tumor treatments currently used in clinical practice are far from satisfactory, due to the specificity of the tumor microenvironment (TME). Identification of diagnostic and therapeutic reagents with strong contrast and therapeutic effect remains a great challenge. Herein, a novel carbon dot nanozyme (Mn‐CD) is synthesized for the first time using toluidine blue (TB) and manganese...
Mesoporous silica nanoparticles (MSNs) have been widely praised as nanoadjuvants in vaccine/tumor immunotherapy thanks to their excellent biocompatibility, easy‐to‐modify surface, adjustable particle size, and remarkable immuno‐enhancing activity. However, the application of MSNs is still greatly limited by some severe challenges including the unclear and complicated relationships of structure and...
Semiconductor crystals have generally shown facet‐dependent electrical, photocatalytic, and optical properties. These phenomena have been proposed to result from the presence of a surface layer with bond‐level deviations. To provide experimental evidence of this structural feature, synchrotron X‐ray sources are used to obtain X‐ray diffraction (XRD) patterns of polyhedral cuprous oxide crystals. Cu...
BaTiO3 octahedra, edge‐, and corner‐truncated cubes, and cubes with four tunable sizes from 132 to 438 nm are synthesized by a solvothermal growth approach. Acetic acid treatment can cleanly remove BaCO3 impurity. Rietveld refinement of X‐ray diffraction patterns and Raman spectra help to confirm the particles have a tetragonal crystal structure. The crystals also exhibit size‐ and facet‐dependent...
Magnetic field enhanced electrocatalysis has recently emerged as a promising strategy for the development of a viable and sustainable hydrogen economy via water oxidation. Generally, the effects of magnetic field enhanced electrocatalysis are complex including magnetothermal, magnetohydrodynamic and spin selectivity effects. However, the exploration of magnetic field effect on the structure regulation...
High Performance Pt–Co Electrocatalysts
Pt–Co electrocatalysts have been widely studied in many electrochemical reactions. In article number 2204100, Jing‐Li Luo, Xian‐Zhu Fu, and co‐workers summarize the recent progress in the syntheses, structure and applications of Pt–Co electrocatalysts. This will help readers to design and understand electrocatalysts for different applications.
Pt–Co electrocatalysts have attracted significant attention because of their excellent performance in many electrochemical reactions. This review focuses on Pt–Co electrocatalysts designed and prepared for electrocatalytic applications. First, the various synthetic methods and synthesis mechanisms are systematically summarized; typical examples and core synthesis parameters are discussed for regulating...
MRSA Phototherapy
In article number 2203292, Weiliang Xia, Yingzheng Zhao, Yijie Chen, and co‐workers show that Van‐Lipo(IR780)‐PFC (an oxygen‐carrying perfluorocarbon nanoemulsion stabilized by a vancomycin‐functionalized sphingo‐myelin liposome loaded with IR780) can capture methicillin‐resistant Staphylococcus aureus (MRSA) toxins in situ, resulting in the on‐demand release of phototherapeutic...
An effective therapeutic strategy against methicillin‐resistant Staphylococcus aureus (MRSA) that does not promote further drug resistance is highly desirable. While phototherapies have demonstrated considerable promise, their application toward bacterial infections can be limited by negative off‐target effects to healthy cells. Here, a smart targeted nanoformulation consisting of a liquid perfluorocarbon...
In spite of the widespread application of vaccine adjuvants in various preventive vaccines at present, the existing adjuvants are still hindered by weak cellular immunity responses in therapeutic cancer vaccines. Herein, a hollow silica nanoadjuvant containing aluminum hydroxide spikes on the surface (SiAl) is synthesized for the co‐loading of chemotherapeutic drug doxorubicin (Dox) and tumor fragment...
Defect states play an important role in the photovoltaic performance of metal halide perovskites. Particularly, the passivation of surface defects has made great contributions to high‐performance perovskite photovoltaics. This highlights the importance of understanding the surface defects from a fundamental level by developing more accurate and operando characterization techniques. Herein, a strategy...
Radical‐containing frameworks (RCFs) have emerged as promising functional materials in various fields due to the combination of the highly ordered frame structure and the fascinating property of organic radicals. Here, the first example of radical‐containing supramolecular organic frameworks (SOFs) fabricated by the chaotropic effect between closo‐dodecaborate cluster (B12H122−) and 2,4,6‐tri(4‐pyridyl)‐1,3,5‐triazine...
The electrochemical oxygen evolution reaction (OER) by efficient catalysts is a crucial step for the conversion of renewable energy into hydrogen fuel, in which surface/near‐surface engineering has been recognized as an effective strategy for enhancing the intrinsic activities of the OER electrocatalysts. Herein, a facile quenching approach is demonstrated that can simultaneously enable the required...
Effects of electronic and atomic structures of V‐doped 2D layered SnS2 are studied using X‐ray spectroscopy for the development of photocatalytic/photovoltaic applications. Extended X‐ray absorption fine structure measurements at V K‐edge reveal the presence of VO and VS bonds which form the intercalation of tetrahedral OVS sites in the van der Waals (vdW) gap of SnS2 layers. X‐ray absorption...
Cellular respiration is the prerequisite for cell survival and functions, and mitochondrial function and microcirculation oxygen supply are essential for cellular respiration. However, in diabetic fracture, cellular respiration of bone marrow stem cells (BMSCs) is disrupted because of the dysfunction of mitochondria and microcirculation disorders. Here, the electrospun fibers of GelMA loaded with...
A cationic monofunctional platinum anticancer drug, phenanthriplatin (PhenPt(II)), exhibits promising anticancer effect on various cancer cell lines. Unlike the conventional platinum(II) drugs, PhenPt(II) is more likely to bind the N7 adenosine base of DNA in situ, and consequently resulting in a unique cellular response profile and unusual potency. However, since this drug is positively charged,...
Colorectal cancer (CRC) ranks as the third common and the fourth lethal cancer type worldwide. Immune checkpoint blockade therapy demonstrates great efficacy in a subset of metastatic CRC patients, but precise activation of the antitumor immune response at the tumor site is still challenging. Here a versatile prodrug nanoparticle for second near‐infrared (NIR‐II) fluorescence imaging‐guided combinatory...
Various organic nanoagents have been developed for photothermal therapy (PTT) and photodynamic therapy (PDT) under near‐infrared (NIR) irradiation. Among them, small molecule‐based nanoagents are very attractive due to their advantages of well‐defined chemical structures, high purity, good reproducibility, and easy processability. However, only a few small molecule‐based nanoagents have been developed...
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