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An anti-angiogenic effect of bisphosphonates has been reported in different experimental models. Zoledronic acid is currently administered in osteoporotic patients as a single 5 mg injection once a year and its vascular effect in bone has not been yet evaluated.The vascular dose effect of a single injection of zoledronic acid was evaluated on healing vascularization developed under a bone chamber...
Summary We evaluated the impact of high dose of zoledronic acid on the superficial vascular network parameters of a membranous bone site. During a 5-day follow-up, significant reduction of the vascular density is observed only in the treated group. Introduction The superficial vascularization is of great importance in membranous bone-healing process. A new rat calvarium intravital model was developed...
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