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The area function method for assessing zero-order (ko) drug absorption rates was compared to four other methods under conditions where variation occurs in the plasma concentration data and in the elimination rate constant (kel or k10) for one- or two-compartment models. For deviant kel values of a one-compartment model, the most accurate recovery of ko occurred with the area function method and...
An equation for the mean residence time (MRT) of drug in the body is derived for the system where drug is injected intravenously into a one-compartment model and eliminated by a single, capacity-limited process. This MRT is a complex function of dose, volume, Vm, and Km but degenerates into the classical volume/clearance expression under limiting low-dose conditions (Km ≫ C0). The equation was...
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