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Background
Most breast cancers (BCs) in men are hormone receptor–positive. Adjuvant tamoxifen is part of the standard treatment of these patients. Small, single‐institution studies have suggested that men have high rates of discontinuing adjuvant endocrine treatment. The authors examined rates of tamoxifen discontinuation and medication adherence in a large population‐based cohort of male patients...
Background
Patients with ovarian cancer often present with late‐stage disease and nonspecific symptoms, but little is known about factors affecting the time to diagnosis (TTD) in the United States.
Methods
A retrospective, population‐based study of the Surveillance, Epidemiology, and End Results–Medicare database was conducted. It included women 66 years old or older with stage II to IV epithelial...
Background
Guidelines for follow‐up after head and neck cancer (HNC) treatment recommend frequent clinical examinations and surveillance testing. Here, the authors describe real‐world follow‐up care for HNC survivors and variations in surveillance testing.
Methods
Using Surveillance, Epidemiology, and End Results (SEER)–Medicare data, this study examined a population‐based cohort of HNC survivors...
Background
Bisphosphonates and denosumab, as adjuvant therapy in breast cancer, have been associated in some studies with improved cancer outcomes. The potential benefits of these drugs used at the lower doses commonly given for osteoporosis have not been established. The objective of this study was to investigate the association between therapy with bone‐modifying agents (BMAs) and survival in older...
BACKGROUND
Chemotherapy for early breast cancer is associated with a small risk of developing myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML). The aim of this study was to determine the risk of developing AML or MDS after modern adjuvant chemotherapy in older breast cancer patients and to further define the risk of individual chemotherapy regimens.
METHODS
Patients diagnosed...
BACKGROUND
Treatment guidelines for colon cancer recommend colectomy with lymphadenectomy of at least 12 lymph nodes for patients with stage I to stage III disease as surgery adherence (SA) and adjuvant chemotherapy for individuals with stage III disease. Herein, the authors evaluated adherence to these guidelines among older patients in Texas with colon cancer and the associated survival outcomes...
BACKGROUND
The National Surgical Adjuvant Breast and Bowel Project B35 and International Breast Cancer Intervention Studies II Ductal Carcinoma In Situ trials showed similar treatment effects of anastrozole and tamoxifen in reducing cancer recurrence risk among ductal carcinoma in situ (DCIS) patients. Studies have shown low levels of hormone therapy drug initiation for DCIS patients, but the current...
BACKGROUND
One goal for high‐quality patient care is communicating treatment costs to patients, yet cost information can be elusive. This is especially relevant for breast cancer care, for which numerous guideline‐concordant adjuvant chemotherapy regimens exist. The objective of the current study was to generate cost estimates for such regimens from payers’ and patients’ perspectives in a large,...
BACKGROUND:The prognosis of acute promyelocytic leukemia (APL) in the elderly is poorer than that of younger patients after treatment with all‐trans retinoic acid plus chemotherapy, which is the current standard therapy for APL. A significantly higher mortality during consolidation therapy was found, which is mainly due to deaths from sepsis following chemotherapy‐induced myelosuppression.
METHODS:A...
BACKGROUND:The scientific literature to date lacks population‐based studies on the demographics, clinical features, and survival of patients with adenoid cystic carcinoma (ACC) of different anatomic sites.
METHODS:The authors identified 5349 patients who had ACC of the major salivary glands (N = 1850), minor salivary glands (N = 2077), breast (N = 696), skin (N = 291), lung and bronchus (N = 203),...
BACKGROUND:The authors evaluated the patterns of use and the risk of thromboembolic events (TEE) associated with erythropoietin‐stimulating agents (ESAs) in older patients with metastatic breast cancer who were receiving chemotherapy.
METHODS:The study was retrospective and used the SEER‐Medicare linked database. Stage IV breast cancer patients diagnosed from 1995‐2005, treated with chemotherapy,...
BACKGROUND:The authors conducted a hospital‐based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from...
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