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Compound 48 (C48) is a novel dual ligand for peroxisome proliferator-activated receptor α and γ (PPARα/γ). Culture of imatinib-sensitive and -resistant CML cell lines with C48 resulted in a strong growth inhibition which associated with G0/G1 cell cycle arrest. However, it showed no obvious toxicity to normal CD34 + hematopoietic stem cells. Decrease of pSTATs and pAKT were noticed suggesting...
This study examined the expression and structural intactness of peroxisome proliferator-activated receptor γ (PPARγ) in human acute lymphocytic leukemia (ALL) cells and determined the effect of PPARγ ligands on growth and apoptosis of these cells. We noted that all lymphocytic leukemia cell lines expressed PPARγ and no PPARγ mutations were found in these cell lines as indicated by SSCP analysis. Effect...
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