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Ultrasmall gold nanoparticles (2 nm) easily penetrate the membranes of intestinal murine epithelial cells (MODE‐K) and colorectal cancer cells (CT‐26). They are also taken up by 3D spheroids (400 µm) of these cell types and primary gut organoids (500 µm). In contrast, dissolved dyes are not taken up by any of these cells or 3D structures. The distribution of fluorescent ultrasmall gold nanoparticles...
Ultrasmall Gold Nanoparticles
Three‐dimensional cell culture models represent a bridge between conventional two‐dimensional cell culture studies and in‐vivo animal experiments. In article number 2201167, Astrid M. Westendorf, Matthias Epple, and co‐workers demonstrate the cytostatic action of doxorubicin‐carrying ultrasmall gold nanoparticles, including their superior ability to enter the three‐dimensional...
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