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Behavioral and biochemical studies have suggested a functional link between the endogenous cannabinoid and opioid systems. Different hypotheses have been proposed to explain the interactions between opioid and cannabinoid systems such as a common pathway stimulating the dopaminergic system, a facilitation of signal-transduction- and/or a cannabinoid-induced enhancement of opioid peptide release. However,...
The present study was designed to assess whether adenosine A 2a receptor knockout mice exhibit altered purine utilisation in brain nuclei. Specifically, the properties of adenosine transporters and adenosine A 1 receptors were characterised in brain membranes and on slide-mounted sections. The B MAX for [ 3 H]nitrobenzylthioinosine ([ 3 H]NBTI)...
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