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In chronic beryllium disease (CBD), a granulomatous lung disease characterized by hypersensitivity to beryllium salts (BE), BE challenge of bronchoalveolar lavage cells induces IFNγ. Although nitric oxide (NO) is elevated in CBD airways, the effects of NO on CBD IFNγ responses are unknown. Here we report that BE-stimulated IFNγ production in CBD lavage cells was markedly reduced (74%) by the NO generator...
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