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In vitro and animals models have shown follicle-stimulating hormone (FSH) effects on osteoclastic function, and FSH levels seem to influence bone loss independently of estrogen concentrations in humans. Our aim was to evaluate the role of serum FSH measurement in the assessment of bone resorption in postmenopausal women. We conducted a cross-sectional study including 92 postmenopausal healthy women...
The expression of aromatase, the enzyme that transforms testosterone into estradiol, was analyzed by reverse transcriptase polymerase chain reaction in the inferior olive of adult male rats. The expression of this messenger in the inferior olive suggests that this brain area may be able to synthesize estradiol. The neuroprotective role of estradiol in the inferior olive was then assessed in a model...
Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEA-S) exert multiple effects in rodent and human brain. Several findings suggest that insulin-like growth factor-1 (IGF-1) is involved in the actions of DHEA. In this study, we assessed whether systemic administration of DHEA regulates the IGF-1 system in the hypothalamus, hippocampus, cerebral cortex, and cerebellum of adult rats. DHEA resulted...
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