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The major histocompatibility complex class II subunits (MHC-II) α and β assemble with the invariant chain (Ii) in the endoplasmic reticulum and are transported to endosomal–lysosomal organelles known as MHC class II compartments (MIICs). Although it has been shown that two dileucine-based signals in the cytosolic tail of Ii, as well as a dileucine-based signal in the tail of the β chain mediate sorting...
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