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Background: Vascular growth factors and their receptors, i.e. Fibroblast Growth Factor Receptor (FGF-R), are considered to be involved in carotid plaque formation. They are putatively responsible for smooth muscle cell (SMC) proliferation, dedifferentiation and apoptosis.Methods: We analyzed 26 human carotid plaques removed by surgery, using immunohistochemistry (TUNEL test to detect fragmented DNA...
Background: Our current understanding of the role of Chlamydia pneumoniae in arteriosclerosis is based on seroepidemiologic and preliminary laboratory data. However, there remains a body of uncertainty about the specific pathogenic mechanisms that may contribute to intimal disease.Methods: Human coronary and carotid plaques (n = 32) removed by percutaneous atherectomy or surgery were examined for...
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