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The effect of environmental humidity and additional water added on the polymorphic change of famotidine in the process of grinding was investigated. The famotidine form B powder with or without additional amount of water added was respectively ground for 30min in an oscillatory ball mill under 25±2°C and three relative humidities (RH) (50±5%, 75±5% or 95±5% RH). Each ground sample was periodically...
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