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Gastric cancer (GC) seriously threatens human health. High mobility group protein B1 (HMGB1) and M2‐like macrophages are closely associated with core events about human cancers, such as invasion, and metastasis, and cancer microenvironment. This study mainly determined the regulatory effect of HMGB1 in GC cell‐derived exosomes on M2‐like macrophage polarization as well as the underlying mechanism...