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The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is known to have a homing effect, recruiting endothelial progenitor cells (EPCs) from the bone marrow to ischemic foci. In this study, we investigated whether SDF-1 is triggered by hypoxia and might be a major driving force for tumor angiogenesis in pituitary adenomas. SDF-1 and microvascular density (MVD) were detected by double-immunofluorescence...
Hypoxia-inducible factor (HIF)-1α is a crucial transcription factor involved in the adaptive response to hypoxia, whereas cathepsin D, which regulates angiostatin in several cancer cell lines, has been reported to be upregulated by HIF-1α. In order to determine the involvement of angiogenesis in pituitary adenomas, we studied the expression of both HIF-1α and cathepsin D in tissues from 58 patients...
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