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Previously our laboratory has shown that ketamine exposure (24h of clinically relevant anesthesia) causes significant increases in neuronal cell death in perinatal rhesus monkeys. Sensitivity to this ketamine-induced neurotoxicity was observed on gestational days 120–123 (in utero exposure via maternal anesthesia) and on postnatal days (PNDs) 5–6, but not on PNDs 35–37. In the present study, six monkeys...
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