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Targeted Protein Deliveries
In article number 2204620, Hak‐Sung Kim and co‐workers develop a new type of protein self‐assembly using human clathrin for a targeted protein delivery. A redesigned clathrin triskelion is dual‐functionalized with functional biomolecules. The resulting clathrin assembly exhibits a significantly high avidity and an efficient delivery of a protein cargo into tumor cells....
Protein assemblies have drawn much attention as platforms for biomedical applications, including gene/drug delivery and vaccine, due to biocompatibility and functional diversity. Here, the construction and functionalization of a protein assembly composed of human clathrin heavy chain and light chain for a targeted protein delivery, is presented. The clathrin heavy and light chains are redesigned and...
In article number 1802618, Joong‐jae Lee, Hak‐Sung Kim, and co‐workers develop an intracellular protein delivery system by sequence specific DNA‐protein interactions for targeted therapy. Engineered nucleoproteins are sequentially assembled onto the surface of gold nanoparticles. The resulting nucleoprotein nanoparticles exhibit highly programmable designability for functional protein loading, and...
With a growing number of intracellular drug targets and the high efficacy of protein therapeutics, the targeted delivery of active proteins with negligible toxicity is a challenging issue in the field of precision medicine. Herein, a programed assembly of nucleoprotein nanoparticles (NNPs) using DNA and zinc fingers (ZnFs) for targeted protein delivery is presented. Two types of ZnFs with different...
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