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The ten eleven translocation (Tet) family of proteins includes three members (Tet1–3), all of which have the capacity to convert 5-methylcytosine to 5-hydroxymethylcytosine in a 2-oxoglutarate- and Fe(II)-dependent manner. Tet1 and Tet2 are highly expressed in undifferentiated embryonic stem cells (ESCs), and this expression decreases upon differentiation. Notably, the expression patterns of Tet1...
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