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mRNA Therapeutics
In article number 2304296, Wenguo Cui, Xiaohua Yu, Zhaoming Ye, and co‐workers report a cytokine efficacy recovery system (CERS), inspired by kinetic energy recovery systems (KERS) in hybrid vehicles, designed to substantially augment the therapeutic index of mRNA‐based tumor immunotherapy via a “capture and stabilize” mechanism exerted by a nanostructured mineral coating carrying...
Tumor‐associated macrophage (TAM) reprogramming is a promising therapeutic approach for cancer immunotherapy; however, its efficacy remains modest due to the low bioactivity of the recombinant cytokines used for TAM reprogramming. mRNA therapeutics are capable of generating fully functional proteins for various therapeutic purposes but accused for its poor sustainability. Inspired by kinetic energy...