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Aims
To examine the effects of Abn‐CBD (GPR55 agonist) and LH‐21 (CB1 antagonist) on human and mouse islet function, and to determine signalling via GPR55 using islets from GPR55−/− mice.
Materials and methods
Islets isolated from human organ donors and mice were incubated in the absence or presence of Abn‐CBD or LH‐21, and insulin secretion, [Ca2+]i, cAMP, apoptosis, β‐cell proliferation and CREB...
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