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A new plasmid-borne gene, dhfrVIII, encoding high-level trimethoprim resistance (Tp R ) was found in an intestinalEscherichia coli . It seems to be a widely occurring mediator of Tp R . Among 973 examined Tp R E. coli, the new resistance gene was found in 13 (1.3%) isolates from Sweden, Finland and Nigeria. The new gene was sequenced and found to code for a dihydrofolate...
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