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In the present study, we have designed 50 novel 1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid analogs as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Docking studies of the designed analogs were performed by molecular modeling software autodock 4.2 using HIV-1 reverse transcriptase (PDB ID: 1rt2) as receptor. Lipinski rule of five parameters and toxicity parameters...
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