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An efficient double Michael addition of nitromethane to divinyl ketones was established in good to high yields (75–99%). A wide range of cyclohexanones were obtained with excellent diastereocontrol (up to >20:1 dr) and enantioinduction (91–99% ee) in a one-pot fashion. The involvement of basic additive significantly enhanced the reactivity of this cascade sequence.
A new protocol for the organocatalytic asymmetric Michael addition of malononitrile to α,β-unsaturated pyrazolamides is reported. The Michael reaction proceeded smoothly in the presence of a bifunctional thiourea and provided the desired adducts in moderate to excellent yields (27–99%) and good to excellent enantioselectivities (80–95% ee).
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