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1-β-d-Arabinofuranosylcytosine (Ara-C, Cytarabine) is one of the drugs used for acute nonlymphocytic leukemia (ANLL). However, the bioavailability of Ara-C is relatively low due to its low lipophilicity. In order to improve the lipophilicity and bioavailability of Ara-C, a series of N 4 derivatives of Ara-C, i.e., (fatty acid)–(amino acid)–Ara-C analogues, were prepared. The 15 derivatives...
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