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DNA microarray is an increasingly important technique that allows biologists to monitor expression levels of thousands of genes in parallel. This technique is widely used in biological research for studying genomic aberrations in cancer and other genetic diseases, and therefore, it has great potential for clinical diagnostics in the future. However, there are still several critical problems with this...
Gridding and spot segmentation are two critical steps in microarray gene expression data analysis. However, the problems of noise contamination and donut-shaped spots often make signal extraction process a labor intensive task. In this paper, we propose a three-step method for automatic gridding and spot segmentation. The method starts with a background removal and noise eliminating step, and then...
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