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An important task of aging research is to find genes that regulate lifespan. Wet-lab identification of aging genes is tedious and labor-intensive activity. Developing an algorithm to predict aging genes will be greatly helpful. In this paper, we systematically analyzed topological features of proteins encoded by Drosophila melanogaster aging genes versus those encoded by non-aging genes in protein-protein...
An important task of aging research is to find genes that regulate lifespan. Wet-lab identification of aging genes is a tedious and labor-intensive activity. Developing an algorithm to predict aging genes for guiding wet-lab experiment should be greatly helpful. In this paper, we systematically analyzed topological features of proteins encoded by Mus musculus aging genes versus those encoded by non-aging...
Identifying the ion types for a mass spectrum is essential for interpreting the spectrum and deriving its peptide sequence. In this paper, we proposed a novel method for identifying ion types and deriving matched peptide sequences for tandem mass spectra. We first divided our dataset into a training set and a testing set and then preprocessed the data using a Support Vector Machine and a 5-fold cross...
Aging is a complex process associated with a number of molecular events at multidimensional levels. Understanding the characteristics of aging is important for elaborating the molecular mechanism of many diseases such as Alzheimer. In this paper, we systematically analyzed topological features of proteins encoded by human aging genes versus those encoded by non-aging genes in protein-protein interaction...
One key element in understanding the molecular machinery of the cell is to understand the structure and function of each protein encoded in the genome. A very successful means of inferring the structure or function of a previously un-annotated protein is via sequence homology with one or more protein whose structure or function is already known. In this paper, a novel method for protein remote homology...
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