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The itch-associated responses evoked by intradermal injection of 12(S)-HPETE and leukotriene B 4 were compared in ICR-mice. 12(S)-HPETE and leukotriene B 4 (0.01–0.2 nmol/site) induced scratching of the injected site, respectively; the dose-responses were a peak at 0.05 nmol/site (12(S)-HPETE) or 0.03 nmol/site (leukotriene B 4 ). The scratching response by 12(S)-HPETE (0.05 nmol/site)...
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