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Heterodimeric tryptophan‐containing diketopiperazines (HTDKPs) are an important class of bioactive secondary metabolites. Biosynthesis offers a practical opportunity to access their bioactive structural diversity, however, it is restricted by the limited substrate scopes of the HTDKPs‐forming P450 dimerases. Herein, by genome mining and investigation of the sequence‐product relationships, we unveiled...
Heterodimeric tryptophan‐containing diketopiperazines (HTDKPs) are an important class of bioactive secondary metabolites. Biosynthesis offers a practical opportunity to access their bioactive structural diversity, however, it is restricted by the limited substrate scopes of the HTDKPs‐forming P450 dimerases. Herein, by genome mining and investigation of the sequence‐product relationships, we unveiled...