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Atomic force microscopy (AFM) offers an exciting tool for quantitatively investigating the physiological activities at single‐cell and single‐molecule levels. Here, we describe the applications of AFM single‐molecule force spectroscopy (SMFS) in investigating the molecular specific interactions on the cell surface. This chapter begins with an introduction to the rituximab (an anti‐CD20 antibody)–targeted...
Knowledge of drug–target interaction is critical to our understanding of drug action and can help design better drugs. Due to the lack of adequate single‐molecule techniques, the information of individual interactions between ligand‐receptors is scarce until the advent of atomic force microscopy (AFM) that can be used to directly measure the individual ligand‐receptor forces under near‐physiological...
Atomic force microscopy (AFM) provides a new technology to visualize the cellular topography and quantify the molecular interactions at nanometer spatial resolution. In this work, AFM was used to image the cellular topography and measure the molecular force of pathological cells from B‐cell lymphoma patients. After the fluorescence staining, cancer cells were recognized by their special morphological...
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