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After remaining an orphan for over a decade, the ykkC riboswitch family (ykkC, mini‐ykkC, and ykkC‐III) was recently characterized as guanidine‐specific genetic regulatory elements (guanidine‐I, II, and III). They respond to increased levels of intracellular guanidine by turning on genes involved in guanidine export and breakdown. Their existence suggests that regulation of intracellular guanidine...
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