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The 17β-hydroxysteroid dehydrogenases (17β-HSDs) are members of a family of enzymes that catalyze the interconversion of weakly active sexual hormones (ketosteroids) and potent hormones (17β-hydroxysteroids). Among the known isoforms of 17β-HSD, the type 1 catalyzes the NAD(P)H-mediated reduction of estrone (E 1 ) to estradiol (E 2 ), a predominant mitogen for the breast cancer cells...
17β-Hydroxysteroid dehydrogenase (17β-HSD) controls the last step in the formation of all androgens and all estrogens. This crucial role of 17β-HSD is performed by at least five 17β-HSD isoenzymes having individual cell-specific expression, substrate specificity, regulation mechanisms, and reductive or oxidative catalytic activity. Both estrogenic and androgenic 17β-HSD activities were found in...
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