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The blood‐brain barrier (BBB) protects the central nervous system (CNS) from harmful elements, while it also restricts efficient drug delivery into the CNS. Previously, we generated a mutated fragment of Clostridium perfringens enterotoxin (cCPEYWSH) which specifically binds to the endothelial tight junction protein claudin‐5. Here, we explore the mechanisms regulating the dynamics of membranous claudin‐5...
The functions of some essential autophagy genes are regulated by microRNAs. However, an ATG3‐modulating microRNA has never been reported. Here we show that the transcription of miR‐495 negatively correlates with the translation of ATG3 under nutrient‐deprived or rapamycin‐treated conditions. miR‐495 targets ATG3 and regulates its protein levels under starvation conditions. miR‐495 also inhibits starvation‐induced...
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