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Three scoring systems were considered and described for dermatological applications in which malignant and benign skin lesions have to be recognized: two models are derived from logistic regression and naïve Bayes rule by rounding model parameters to their nearest integer values; the third approach defines the scoring system by a direct stepwise adding of the most significant binary risk factors....
The aims of this work were the optimization of the IKr model, based on the Luo-Rudy (LRd) formulation by fitting it to IKr recorded as E4031-sensitive current (IE4031) under Action Potential clamp and the validation of the optimized model by testing its suitability to replace native IKr under Dynamic Clamp conditions. We found the experimental IE4031 very different from the IKr based on the LRd model...
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