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Front Cover: A scaffold functionalized by nanosilicate is customized for calvarial bone defect repairing. It exerts osteoblast to induce vascularized bone regeneration through directly orchestrating its osteogenic property, and secreting cytokines to indirectly facilitate angiogenesis of vessel endothelial cells to form new vessels and alleviating osteoclastogenesis of osteoclasts to reduce bone resorption...
Massive oral and maxillofacial bone defect regeneration remains a major clinical challenge due to the absence of functionalized bone grafts with ideal mechanical and proregeneration properties. In the present study, Laponite (LAP), a synthetic nanosilicate, is incorporated into polycaprolactone (PCL) to develop a biomaterial for bone regeneration. It is explored whether LAP‐embedded PCL would accelerate...
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