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Selective estrogen receptor modulators (SERMs) are drugs used to treat osteoporosis. Selective estrogen receptor modulators improve bone mineral density and bone mechanical strength. However, there is a lack of data on the effect of SERMs on osteoporotic spinal fusion.This study aimed to investigate whether treatment with a SERM enhances spinal fusion in an ovariectomized (OVX) rat model.An in vivo...
In osteoporotic patients undergoing spinal arthrodesis, the use of bisphosphonates (BPs) remains controversial with regard to bone fusion. There is no consensus about the appropriate time to give BPs to patients with osteoporosis undergoing spinal arthrodesis.We aimed to study the effect of BPs, given at different times, on the bone response to osteoporotic spinal arthrodesis.Radiological, histologic,...
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