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Bortezomib suppresses ubiquitin (Ub)‐dependent protein degradation and preferentially kills various tumour cells in vitro and in animal models. However, its mechanism of action is not fully understood. We report that bortezomib inhibits the proliferation and proteasomal activity of human endometrial cancer cells and induces G2/M arrest and apoptosis by modulating the miRNA level. By miRNA microarray,...
miR‐128 is more highly expressed in drug‐resistant breast cancer samples than in drug‐sensitive samples. We have confirmed that Bax is the target of miR‐128 by negative post‐transcriptional regulation. miR‐128 and Bax were detected in the breast cancer cell line, MDA‐MB‐231, which was then transfected with miR‐128 MIMIC (precursor of miR‐128) or AMO (antisense‐miR‐128 oligonucleotides). After transfection,...
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