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Purpose In planar 123I-mIBG myocardial imaging, definition of the heart region of interest (ROI) is a critical step in quantifying uptake. The present study evaluated the impact of changes in heart ROI size on quantitative results in subjects with good and poor uptake. Methods Reference irregular whole-heart and square upper mediastinum ROIs were defined visually on 531 planar 123I-mIBG images....
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