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Objective: In vivo visualization and quantification of edema, or ‘tissue swelling’ following injury, remains a clinical challenge. Herein, we investigate the ability of reflective terahertz (THz) imaging to track changes in tissue water content (TWC)—the direct indicator of edema—by comparison to depth-resolved magnetic resonance imaging (MRI) in a burn-induced model of edema. Methods: A partial thickness...
Research into the application of THz frequency imaging to medical diagnostics has yielded a significant body of work reporting the properties of in vitro and ex vivo samples. However, there a dearth of in vivo imaging results owing to the practical difficulties of acquiring data of sufficient fidelity on living animal and/or human subjects. This limited data set has hindered widespread acceptance...
Parallel T2 weighted multi slice multi echo (T2w MSME) 7T Magnetic Resonance (MR) scans and terahertz (THz) surface reflectance maps were acquired of a full thickness skin burn in a rat model to investigate the spatiotemporal evolution of terahertz reflectivity in wound responses. A comparison of uninjured and injured regions in the burn neighborhood demonstrates a 3-fold increase in T2 relaxation...
Electromagnetic modeling predicts that dielectric substrate windows placed above a tissue of interest alter the hydration sensitivity of reflective THz imaging systems. Furthermore, interference effects between layers (the window with the skin layers) cause the window's optical path length to change the depth probed by the imaging system. A pulsed THz imaging system operating at ∼ 500 GHz was used...
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