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A novel biocatalytic route for (S)-3-cyano-5-methylhexanoic acid, the key chiral intermediate of pregabalin, was successfully developed using whole cells of newly isolated Arthrobacter sp. ZJB-09277. Kinetic resolution of a series of rac-3-cyano-5-methylhexanoic acid esters bearing a β-stereocenter indicated that steric effect of the leaving alcohol moiety played an important role in determining activity...
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